Functional Evolution of the HIV-1 Envelope Glycoprotein 120 Association Site of Glycoprotein 41
نویسندگان
چکیده
منابع مشابه
Global site-specific N-glycosylation analysis of HIV envelope glycoprotein
HIV-1 envelope glycoprotein (Env) is the sole target for broadly neutralizing antibodies (bnAbs) and the focus for design of an antibody-based HIV vaccine. The Env trimer is covered by ∼90N-linked glycans, which shield the underlying protein from immune surveillance. bNAbs to HIV develop during infection, with many showing dependence on glycans for binding to Env. The ability to routinely asses...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2003
ISSN: 0021-9258
DOI: 10.1074/jbc.m305223200